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Table 2 Baseline-adjusted mean differences between aclidinium and placebo on lung function parameters at all measured time points throughout the 52-week studies

From: Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease

Parameter

ACCLAIM/COPD I

ACCLAIM/COPD II

Trough FEV1, mL

37-67*

51-78§

Peak FEV1, mL

147-177

141-156

AUC(0-3 h), mL

135-166

133-150

Trough FVC, mL

96-141§

83-148

Peak FVC, mL

275-310

259-315

Trough IC, mL

58-101*

64-135§

Peak IC, mL

166-204

171-220

Morning PEF, mL/min

6.1-13.9*

9.8-17.2*

Evening PEF, mL/min

18.9-22.8

16.9-22.9§

  1. *p < 0.05; §p < 0.01; p < 0.001; p < 0.0001.
  2. Data are reported as the minimum and maximum values over the treatment period; the indicated p-values apply throughout the stated range.
  3. FEV1: forced expiratory volume in 1 second; AUC(0-3 h): area under the curve from 0 to 3 h post-dose; FVC: forced vital capacity; IC: inspiratory capacity; PEF: peak expiratory flow.