Table 1 Parameters of the concentration-response curve to vasoconstrictor agonists in isolated conductance and resistance PA from lean and obese Zucker rats [means ± s.e.m. (n)].
From: Pulmonary arterial dysfunction in insulin resistant obese Zucker rats
| Â | Emax(% of KCl) | pD2 | ||
|---|---|---|---|---|
| Â | Lean | Obese | Lean | Obese |
Conductance PA | Â | Â | Â | Â |
   Phenylephrine | 82.6 ± 3.2 (5) | 83.7 ± 4.1(5) | 8.20 ± 0.03 | 8.10 ± 0.09 |
   5-HT | 64.3 ± 6.5 (5) | 64.4 ± 7.2(5) | 5.28 ± 0.13 | 5.02 ± 0.11 |
   α-methyl-5-HT | 41.0 ± 9.5 (6) | 30.8 ± 6.8(6) | 5.32 ± 0.13 | 5.46 ± 0.12 |
Resistance PA | Â | Â | Â | Â |
   5-HT | 69.2 ± 7.8 (6) | 33.5 ± 9.1 * (6) | 5.28 ± 0.10 | 4.86 ± 0.06 ** |
   5-HT (1400W) | 49 ± 7 (6) | 58 ± 9 (6) | 5.10 ± 0.13 | 5.24 ± 0.15 |
   α-methyl-5-HT | 33.7 ± 8.8 (4) | 9.5 ± 3.6 * (4) | 5.80 ± 0.11 | 5.58 ± 0.10 |