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Figure 6 | Respiratory Research

Figure 6

From: Pulmonary arterial dysfunction in insulin resistant obese Zucker rats

Figure 6

Role of iNOS. (A) Constrictor effect of 5-HT (10-4M) and the additional contractile effect of L-NAME (10-4M) on top of the response to 5-HT in resistance PA from lean (n = 7) and obese (n = 6) Zucker rats. (B) Concentration-response curves to 5-HT in the presence of 1400W (10-5M, n = 6) in resistance PA. (C) iNOS mRNA transcript levels in resistance PA (n = 6), (D) iNOS protein in resistance PA (n = 5 and 6, respectively). Results indicate mean ± s.e.m. * denotes P < 0.05 (obese vs lean, unpaired t test) and # and ## denote P < 0.05 and P < 0.01, respectively (pre vs post L-NAME paired t test).

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