TY - JOUR AU - Morrell, N. W. AU - Adnot, S. AU - Archer, S. L. AU - Dupuis, J. AU - Jones, P. L. AU - MacLean, M. R. AU - McMurtry, I. F. AU - Stenmark, K. R. AU - Thistlethwaite, P. A. AU - Weissmann, N. PY - 2009 DA - 2009// TI - Cellular and molecular basis of pulmonary arterial hypertension JO - J Am Coll Cardiol VL - 54 UR - https://doi.org/10.1016/j.jacc.2009.04.018 DO - 10.1016/j.jacc.2009.04.018 ID - Morrell2009 ER - TY - JOUR AU - Cogolludo, A. AU - Moreno, L. AU - Villamor, E. PY - 2007 DA - 2007// TI - Mechanisms controlling vascular tone in pulmonary arterial hypertension: implications for vasodilator therapy JO - Pharmacology VL - 79 UR - https://doi.org/10.1159/000097754 DO - 10.1159/000097754 ID - Cogolludo2007 ER - TY - JOUR AU - Chan, S. Y. AU - Loscalzo, J. PY - 2008 DA - 2008// TI - Pathogenic mechanisms of pulmonary arterial hypertension JO - J Mol Cell Cardiol VL - 44 UR - https://doi.org/10.1016/j.yjmcc.2007.09.006 DO - 10.1016/j.yjmcc.2007.09.006 ID - Chan2008 ER - TY - JOUR AU - Atkinson, C. AU - Stewart, S. AU - Upton, P. D. AU - Machado, R. AU - Thomson, J. R. AU - Trembath, R. C. AU - Morrell, N. W. PY - 2002 DA - 2002// TI - Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor JO - Circulation VL - 105 UR - https://doi.org/10.1161/01.CIR.0000012754.72951.3D DO - 10.1161/01.CIR.0000012754.72951.3D ID - Atkinson2002 ER - TY - JOUR AU - Morty, R. E. AU - Nejman, B. AU - Kwapiszewska, G. AU - Hecker, M. AU - Zakrzewicz, A. AU - Kouri, F. M. AU - Peters, D. M. AU - Dumitrascu, R. AU - Seeger, W. AU - Knaus, P. PY - 2007 DA - 2007// TI - Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension JO - Arterioscler Thromb Vasc Biol VL - 27 UR - https://doi.org/10.1161/ATVBAHA.107.141200 DO - 10.1161/ATVBAHA.107.141200 ID - Morty2007 ER - TY - JOUR AU - Takahashi, H. AU - Goto, N. AU - Kojima, Y. AU - Tsuda, Y. AU - Morio, Y. AU - Muramatsu, M. AU - Fukuchi, Y. PY - 2006 DA - 2006// TI - Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension JO - Am J Physiol Lung Cell Mol Physiol VL - 290 UR - https://doi.org/10.1152/ajplung.00206.2005 DO - 10.1152/ajplung.00206.2005 ID - Takahashi2006 ER - TY - JOUR AU - Long, L. AU - MacLean, M. R. AU - Jeffery, T. K. AU - Morecroft, I. AU - Yang, X. AU - Rudarakanchana, N. AU - Southwood, M. AU - James, V. AU - Trembath, R. C. AU - Morrell, N. W. PY - 2006 DA - 2006// TI - Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice JO - Circ Res VL - 98 UR - https://doi.org/10.1161/01.RES.0000215809.47923.fd DO - 10.1161/01.RES.0000215809.47923.fd ID - Long2006 ER - TY - JOUR AU - Lopez-Lopez, J. G. AU - Moral-Sanz, J. AU - Frazziano, G. AU - Gomez-Villalobos, M. J. AU - Flores-Hernandez, J. AU - Monjaraz, E. AU - Cogolludo, A. AU - Perez-Vizcaino, F. PY - 2008 DA - 2008// TI - Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction JO - Am J Physiol Lung Cell Mol Physiol VL - 295 UR - https://doi.org/10.1152/ajplung.90354.2008 DO - 10.1152/ajplung.90354.2008 ID - Lopez-Lopez2008 ER - TY - JOUR AU - Rodat, L. AU - Savineau, J. P. AU - Marthan, R. AU - Guibert, C. PY - 2007 DA - 2007// TI - Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries JO - Pflugers Arch VL - 454 UR - https://doi.org/10.1007/s00424-006-0178-y DO - 10.1007/s00424-006-0178-y ID - Rodat2007 ER - TY - JOUR AU - Csiszar, A. AU - Labinskyy, N. AU - Olson, S. AU - Pinto, J. T. AU - Gupte, S. AU - Wu, J. M. AU - Hu, F. AU - Ballabh, P. AU - Podlutsky, A. AU - Losonczy, G. PY - 2009 DA - 2009// TI - Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats JO - Hypertension VL - 54 UR - https://doi.org/10.1161/HYPERTENSIONAHA.109.133397 DO - 10.1161/HYPERTENSIONAHA.109.133397 ID - Csiszar2009 ER - TY - JOUR AU - Hironaka, E. AU - Hongo, M. AU - Sakai, A. AU - Mawatari, E. AU - Terasawa, F. AU - Okumura, N. AU - Yamazaki, A. AU - Ushiyama, Y. AU - Yazaki, Y. AU - Kinoshita, O. PY - 2003 DA - 2003// TI - Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats JO - Cardiovasc Res VL - 60 UR - https://doi.org/10.1016/j.cardiores.2003.09.023 DO - 10.1016/j.cardiores.2003.09.023 ID - Hironaka2003 ER - TY - JOUR AU - Cogolludo, A. AU - Perez-Vizcaino, F. PY - 2010 DA - 2010// TI - 5-HT receptors and K(V) channel internalization JO - Adv Exp Med Biol VL - 661 UR - https://doi.org/10.1007/978-1-60761-500-2_25 DO - 10.1007/978-1-60761-500-2_25 ID - Cogolludo2010 ER - TY - JOUR AU - Remillard, C. V. AU - Tigno, D. D. AU - Platoshyn, O. AU - Burg, E. D. AU - Brevnova, E. E. AU - Conger, D. AU - Nicholson, A. AU - Rana, B. K. AU - Channick, R. N. AU - Rubin, L. J. PY - 2007 DA - 2007// TI - Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension JO - Am J Physiol Cell Physiol VL - 292 UR - https://doi.org/10.1152/ajpcell.00405.2006 DO - 10.1152/ajpcell.00405.2006 ID - Remillard2007 ER - TY - JOUR AU - Yuan, J. X. AU - Aldinger, A. M. AU - Juhaszova, M. AU - Wang, J. AU - Conte, J. V. AU - Gaine, S. P. AU - Orens, J. B. AU - Rubin, L. J. PY - 1998 DA - 1998// TI - Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension JO - Circulation VL - 98 UR - https://doi.org/10.1161/01.CIR.98.14.1400 DO - 10.1161/01.CIR.98.14.1400 ID - Yuan1998 ER - TY - JOUR AU - Kirk, E. P. AU - Klein, S. PY - 2009 DA - 2009// TI - Pathogenesis and pathophysiology of the cardiometabolic syndrome JO - J Clin Hypertens (Greenwich) VL - 11 UR - https://doi.org/10.1111/j.1559-4572.2009.00054.x DO - 10.1111/j.1559-4572.2009.00054.x ID - Kirk2009 ER - TY - JOUR AU - Cherian, B. AU - Meka, N. AU - Katragadda, S. AU - Arora, R. PY - 2009 DA - 2009// TI - Therapeutic implications of diabetes in cardiovascular disease JO - Am J Ther VL - 16 UR - https://doi.org/10.1097/MJT.0b013e31815db924 DO - 10.1097/MJT.0b013e31815db924 ID - Cherian2009 ER - TY - JOUR AU - Fouty, B. PY - 2008 DA - 2008// TI - Diabetes and the pulmonary circulation JO - Am J Physiol Lung Cell Mol Physiol VL - 295 UR - https://doi.org/10.1152/ajplung.90482.2008 DO - 10.1152/ajplung.90482.2008 ID - Fouty2008 ER - TY - JOUR AU - Zamanian, R. T. AU - Hansmann, G. AU - Snook, S. AU - Lilienfeld, D. AU - Rappaport, K. M. AU - Reaven, G. M. AU - Rabinovitch, M. AU - Doyle, R. L. PY - 2009 DA - 2009// TI - Insulin resistance in pulmonary arterial hypertension JO - Eur Respir J VL - 33 UR - https://doi.org/10.1183/09031936.00000508 DO - 10.1183/09031936.00000508 ID - Zamanian2009 ER - TY - JOUR AU - Movahed, M. R. AU - Hashemzadeh, M. AU - Jamal, M. M. PY - 2005 DA - 2005// TI - The prevalence of pulmonary embolism and pulmonary hypertension in patients with type II diabetes mellitus JO - Chest VL - 128 UR - https://doi.org/10.1016/S0012-3692(15)52932-2 DO - 10.1016/S0012-3692(15)52932-2 ID - Movahed2005 ER - TY - JOUR AU - Robbins, I. M. AU - Newman, J. H. AU - Johnson, R. F. AU - Hemnes, A. R. AU - Fremont, R. D. AU - Piana, R. N. AU - Zhao, D. X. AU - Byrne, D. W. PY - 2009 DA - 2009// TI - Association of the metabolic syndrome with pulmonary venous hypertension JO - Chest VL - 136 UR - https://doi.org/10.1378/chest.08-2008 DO - 10.1378/chest.08-2008 ID - Robbins2009 ER - TY - JOUR AU - Hansmann, G. AU - Wagner, R. A. AU - Schellong, S. AU - Perez, V. A. AU - Urashima, T. AU - Wang, L. AU - Sheikh, A. Y. AU - Suen, R. S. AU - Stewart, D. J. AU - Rabinovitch, M. PY - 2007 DA - 2007// TI - Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation JO - Circulation VL - 115 ID - Hansmann2007 ER - TY - JOUR AU - Fredersdorf, S. AU - Thumann, C. AU - Ulucan, C. AU - Griese, D. P. AU - Luchner, A. AU - Riegger, G. A. AU - Kromer, E. P. AU - Weil, J. PY - 2004 DA - 2004// TI - Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats JO - Cardiovasc Pathol VL - 13 UR - https://doi.org/10.1016/S1054-8807(03)00109-1 DO - 10.1016/S1054-8807(03)00109-1 ID - Fredersdorf2004 ER - TY - JOUR AU - Romanko, O. P. AU - Stepp, D. W. PY - 2005 DA - 2005// TI - Reduced constrictor reactivity balances impaired vasodilation in the mesenteric circulation of the obese Zucker rat JO - Am J Physiol Heart Circ Physiol VL - 289 UR - https://doi.org/10.1152/ajpheart.00213.2005 DO - 10.1152/ajpheart.00213.2005 ID - Romanko2005 ER - TY - JOUR AU - Song, D. AU - Yao, R. AU - Pang, C. C. PY - 2008 DA - 2008// TI - Altered vasodilator role of nitric oxide synthase in the pancreas, heart and brain of rats with spontaneous type 2 diabetes JO - Eur J Pharmacol VL - 591 UR - https://doi.org/10.1016/j.ejphar.2008.06.036 DO - 10.1016/j.ejphar.2008.06.036 ID - Song2008 ER - TY - JOUR AU - Cogolludo, A. AU - Moreno, L. AU - Lodi, F. AU - Frazziano, G. AU - Cobeno, L. AU - Tamargo, J. AU - Perez-Vizcaino, F. PY - 2006 DA - 2006// TI - Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization JO - Circ Res VL - 98 UR - https://doi.org/10.1161/01.RES.0000216858.04599.e1 DO - 10.1161/01.RES.0000216858.04599.e1 ID - Cogolludo2006 ER - TY - JOUR AU - Cogolludo, A. AU - Moreno, L. AU - Frazziano, G. AU - Moral-Sanz, J. AU - Menendez, C. AU - Castaneda, J. AU - Gonzalez, C. AU - Villamor, E. AU - Perez-Vizcaino, F. PY - 2009 DA - 2009// TI - Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction JO - Cardiovasc Res VL - 82 UR - https://doi.org/10.1093/cvr/cvn349 DO - 10.1093/cvr/cvn349 ID - Cogolludo2009 ER - TY - JOUR AU - Cogolludo, A. AU - Moreno, L. AU - Lodi, F. AU - Tamargo, J. AU - Perez-Vizcaino, F. PY - 2005 DA - 2005// TI - Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction JO - Cardiovasc Res VL - 66 UR - https://doi.org/10.1016/j.cardiores.2004.12.019 DO - 10.1016/j.cardiores.2004.12.019 ID - Cogolludo2005 ER - TY - JOUR AU - Takaya, K. AU - Ogawa, Y. AU - Isse, N. AU - Okazaki, T. AU - Satoh, N. AU - Masuzaki, H. AU - Mori, K. AU - Tamura, N. AU - Hosoda, K. AU - Nakao, K. PY - 1996 DA - 1996// TI - Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats JO - Biochem Biophys Res Commun VL - 225 UR - https://doi.org/10.1006/bbrc.1996.1133 DO - 10.1006/bbrc.1996.1133 ID - Takaya1996 ER - TY - JOUR AU - Osmond, J. M. AU - Mintz, J. D. AU - Dalton, B. AU - Stepp, D. W. PY - 2009 DA - 2009// TI - Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat JO - Hypertension VL - 53 UR - https://doi.org/10.1161/HYPERTENSIONAHA.108.124149 DO - 10.1161/HYPERTENSIONAHA.108.124149 ID - Osmond2009 ER - TY - JOUR AU - Al-Shafei, A. I. AU - Wise, R. G. AU - Gresham, G. A. AU - Bronns, G. AU - Carpenter, T. A. AU - Hall, L. D. AU - Huang, C. L. PY - 2002 DA - 2002// TI - Non-invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin-converting enzyme inhibition in diabetic rats JO - J Physiol VL - 538 UR - https://doi.org/10.1113/jphysiol.2001.012856 DO - 10.1113/jphysiol.2001.012856 ID - Al-Shafei2002 ER - TY - JOUR AU - Frisbee, J. C. PY - 2005 DA - 2005// TI - Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome JO - Am J Physiol Regul Integr Comp Physiol VL - 289 UR - https://doi.org/10.1152/ajpregu.00114.2005 DO - 10.1152/ajpregu.00114.2005 ID - Frisbee2005 ER - TY - JOUR AU - Villalba, N. AU - Martinez, P. AU - Briones, A. M. AU - Sanchez, A. AU - Salaices, M. AU - Garcia-Sacristan, A. AU - Hernandez, M. AU - Benedito, S. AU - Prieto, D. PY - 2009 DA - 2009// TI - Differential structural and functional changes in penile and coronary arteries from obese Zucker rats JO - Am J Physiol Heart Circ Physiol VL - 297 UR - https://doi.org/10.1152/ajpheart.01308.2008 DO - 10.1152/ajpheart.01308.2008 ID - Villalba2009 ER - TY - JOUR AU - Serpillon, S. AU - Floyd, B. C. AU - Gupte, R. S. AU - George, S. AU - Kozicky, M. AU - Neito, V. AU - Recchia, F. AU - Stanley, W. AU - Wolin, M. S. AU - Gupte, S. A. PY - 2009 DA - 2009// TI - Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH JO - Am J Physiol Heart Circ Physiol VL - 297 UR - https://doi.org/10.1152/ajpheart.01142.2008 DO - 10.1152/ajpheart.01142.2008 ID - Serpillon2009 ER - TY - JOUR AU - Stehouwer, C. D. AU - Lambert, J. AU - Donker, A. J. AU - van Hinsbergh, V. W. PY - 1997 DA - 1997// TI - Endothelial dysfunction and pathogenesis of diabetic angiopathy JO - Cardiovasc Res VL - 34 UR - https://doi.org/10.1016/S0008-6363(96)00272-6 DO - 10.1016/S0008-6363(96)00272-6 ID - Stehouwer1997 ER - TY - JOUR AU - Jay, D. AU - Hitomi, H. AU - Griendling, K. K. PY - 2006 DA - 2006// TI - Oxidative stress and diabetic cardiovascular complications JO - Free Radic Biol Med VL - 40 UR - https://doi.org/10.1016/j.freeradbiomed.2005.06.018 DO - 10.1016/j.freeradbiomed.2005.06.018 ID - Jay2006 ER - TY - JOUR AU - Coggins, M. P. AU - Bloch, K. D. PY - 2007 DA - 2007// TI - Nitric oxide in the pulmonary vasculature JO - Arterioscler Thromb Vasc Biol VL - 27 UR - https://doi.org/10.1161/ATVBAHA.107.142943 DO - 10.1161/ATVBAHA.107.142943 ID - Coggins2007 ER - TY - JOUR AU - Toblli, J. AU - Cao, G. AU - Rivas, C. AU - Munoz, M. AU - Giani, J. AU - Dominici, F. AU - Angerosa, M. PY - 2010 DA - 2010// TI - Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats JO - J Hypertens VL - 28 UR - https://doi.org/10.1097/HJH.0b013e328337598c DO - 10.1097/HJH.0b013e328337598c ID - Toblli2010 ER - TY - JOUR AU - Fulton, D. AU - Harris, M. B. AU - Kemp, B. E. AU - Venema, R. C. AU - Marrero, M. B. AU - Stepp, D. W. PY - 2004 DA - 2004// TI - Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90 JO - Am J Physiol Heart Circ Physiol VL - 287 UR - https://doi.org/10.1152/ajpheart.00280.2004 DO - 10.1152/ajpheart.00280.2004 ID - Fulton2004 ER - TY - JOUR AU - Gurney, A. M. AU - Howarth, F. C. PY - 2009 DA - 2009// TI - Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries JO - Cardiovasc Diabetol VL - 8 UR - https://doi.org/10.1186/1475-2840-8-4 DO - 10.1186/1475-2840-8-4 ID - Gurney2009 ER - TY - JOUR AU - Song, D. AU - Kuo, K. H. AU - Yao, R. AU - Hutchings, S. R. AU - Pang, C. C. PY - 2008 DA - 2008// TI - Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats JO - Eur J Pharmacol VL - 579 UR - https://doi.org/10.1016/j.ejphar.2007.09.043 DO - 10.1016/j.ejphar.2007.09.043 ID - Song2008 ER - TY - JOUR AU - Gunnett, C. A. AU - Heistad, D. D. AU - Faraci, F. M. PY - 2003 DA - 2003// TI - Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes JO - Stroke VL - 34 UR - https://doi.org/10.1161/01.STR.0000099123.55171.3F DO - 10.1161/01.STR.0000099123.55171.3F ID - Gunnett2003 ER - TY - JOUR AU - Noronha, B. T. AU - Li, J. M. AU - Wheatcroft, S. B. AU - Shah, A. M. AU - Kearney, M. T. PY - 2005 DA - 2005// TI - Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity JO - Diabetes VL - 54 UR - https://doi.org/10.2337/diabetes.54.4.1082 DO - 10.2337/diabetes.54.4.1082 ID - Noronha2005 ER - TY - JOUR AU - Rivera, L. AU - Moron, R. AU - Sanchez, M. AU - Zarzuelo, A. AU - Galisteo, M. PY - 2008 DA - 2008// TI - Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats JO - Obesity (Silver Spring) VL - 16 UR - https://doi.org/10.1038/oby.2008.315 DO - 10.1038/oby.2008.315 ID - Rivera2008 ER - TY - JOUR AU - Chauhan, S. D. AU - Seggara, G. AU - Vo, P. A. AU - Macallister, R. J. AU - Hobbs, A. J. AU - Ahluwalia, A. PY - 2003 DA - 2003// TI - Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice JO - FASEB J VL - 17 ID - Chauhan2003 ER - TY - JOUR AU - Cuzzocrea, S. AU - Mazzon, E. AU - Di Paola, R. AU - Esposito, E. AU - Macarthur, H. AU - Matuschak, G. M. AU - Salvemini, D. PY - 2006 DA - 2006// TI - A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock JO - J Pharmacol Exp Ther VL - 319 UR - https://doi.org/10.1124/jpet.106.108100 DO - 10.1124/jpet.106.108100 ID - Cuzzocrea2006 ER -