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Figure 5 | Respiratory Research

Figure 5

From: Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells

Figure 5

Anti-OVA IgG1 increased allergic airway inflammation in FcγRIIB KO mice, and BMDCs transplantation reversed its effects. A, Total cell, eosinophil and the others cell counts of BAL fluid obtained from OVA-sensitized and challenged FcγRIIB KO mice (IIBKO) instilled with PBS or anti-OVAIgG1. Moreover, FcγRIIB KO mice intravenously transplanted with WT-derived BMDCs (IIBKO/DC i.v. IgG1) were sensitized and challenged with OVA, and instilled intratracheally with anti-OVA IgG1. The number of BAL fluid was analysed. Data show mean ± SEM. #: p < 0.05 vs. WT/PBS, ‡: p < 0.05 vs. IIBKO/PBS. B, Histological examination of lung tissues of FcγRIIB KO mice instilled with PBS and anti-OVA IgG1. Micrographs (high magnification, ×400) depict lung sections stained with H&E.

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