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Figure 4 | Respiratory Research

Figure 4

From: Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis

Figure 4

Effects of adrenomedullin (AM) on bleomycin (BLM)-induced iNOS expression. Immunohistochemical localization for iNOS revealed a positive staining for this enzyme in lung sections obtained from BLM-treated mice (B). In BLM mice treated with AM, the staining for iNOS (C) was significantly reduced when compared with BLM mice. No positive staining for iNOS was observed in lung tissues obtained from sham-operated mice (A). Densitometry analysis of immunohistochemistry photographs (n = 5 photos from each sample collected from all mice in each experimental group) for iNOS was assessed (D). The assay was carried out by using AxioVision on a personal computer. The figure is representative of at least three experiments performed on different experimental days. Data are expressed as % of total tissue area and are mean ± standard deviation from n = 10 mice for each group. *P < 0.01 vs sham, °P < 0.01 vs bleomycin+ vehicle.

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