Table 4 Relationships between mean change in FEV₁ and the outcomes Transition Dyspnea Index (TDI) and percentage of patients experiencing at least one exacerbation for all treatments (LAMA, LABA, LAMA + LABA) and placebo: correlation coefficients and model outputs

Data points (n)

15

50

Correlation between change in outcome and change in FEV₁ (r*)

0.56

-0.27

p value

0.02

0.049

Outcome change for 0 mL change in FEV₁ (95% CI)**

0.7 (0.3, 1.2)

26.7 (21.7, 31.3)%

Additional change in outcome for 100 mL change in FEV₁ (95% CI)**

0.5 (0.1, 0.9)

-6.0 (-0.04,-11.9)%