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Table 4 Relationships between mean change in FEV1 and the outcomes Transition Dyspnea Index (TDI) and percentage of patients experiencing at least one exacerbation for all treatments (LAMA, LABA, LAMA + LABA) and placebo: correlation coefficients and model outputs

From: Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review

  Outcome
  TDI total score Percent of patients experiencing at least one exacerbation
Data points (n) 15 50
Correlation between change in outcome and change in FEV1 (r*) 0.56 -0.27
p value 0.02 0.049
Outcome change for 0 mL change in FEV1 (95% CI)** 0.7 (0.3, 1.2) 26.7 (21.7, 31.3)%
Additional change in outcome for 100 mL change in FEV1 (95% CI)** 0.5 (0.1, 0.9) -6.0 (-0.04,-11.9)%
  1. *Pearson correlation coefficient; **output from random effects regression modelling
  2. FEV1: forced expiratory volume in 1 second, LAMA: long-acting muscarinic antagonists, LABA: long-acting β2-agonists