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Table 3 Correlations for mean change in FEV1 for all treatments (LAMA, LABA, LAMA + LABA) and placebo versus reduction in SGRQ scores at a study level, by study period and SGRQ domain

From: Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review

SGRQ Study period Data points, n Correlation, r* p value
Total score All 49 -0.46 <0.001
  3 months 16 -0.44 0.08
  6 months 20 -0.61 0.004
  12 months 19 -0.74 <0.001
Symptoms All 27 -0.34 0.08
Activity All 27 -0.38 0.049
Impact All 30 -0.50 0.004
  1. *Pearson correlation coefficient
  2. FEV1: forced expiratory volume in 1 second, LAMA: long-acting muscarinic antagonists, LABA: long-acting β2-agonists, SGRQ: St George's Respiratory Questionnaire
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Respiratory Research

ISSN: 1465-993X

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