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Table 3 Correlations for mean change in FEV1 for all treatments (LAMA, LABA, LAMA + LABA) and placebo versus reduction in SGRQ scores at a study level, by study period and SGRQ domain

From: Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review

SGRQ

Study period

Data points, n

Correlation, r*

p value

Total score

All

49

-0.46

<0.001

 

3 months

16

-0.44

0.08

 

6 months

20

-0.61

0.004

 

12 months

19

-0.74

<0.001

Symptoms

All

27

-0.34

0.08

Activity

All

27

-0.38

0.049

Impact

All

30

-0.50

0.004

  1. *Pearson correlation coefficient
  2. FEV1: forced expiratory volume in 1 second, LAMA: long-acting muscarinic antagonists, LABA: long-acting β2-agonists, SGRQ: St George's Respiratory Questionnaire