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Figure 4 | Respiratory Research

Figure 4

From: Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells

Figure 4

Increase in the ER stress chaperone BiP in A549 cells expressing R280C and L101P mutations. (A) A549 cells with ER retained L101P mutant or partially ER retained R280C protein showed upregulation of the immunodetected ER chaperone BiP in comparison to WT and A549 cells. BiP was drastically upregulated after 14 h treatment of A549 cells with 10 μg/ml of the ER stressor tunicamycin (TM). (B) Densitometric quantification of the BiP protein level of four independent experiments, without the drastic effect of TM treatment, is presented; * p < 0.05, ** p < 0.01.

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