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Figure 6 | Respiratory Research

Figure 6

From: Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation

Figure 6

BRP-39 is not required for cigarette smoke induced allergic sensitization. BALB/c and BRP-39 KO mice were saline (white bars) or HDM (grey bars) exposed for 10 days. (A) Data show total cell numbers (TCN), mononuclear cells (MNC), neutrophils (NEU), and eosinophils (EOS) in bronchoalveolar lavage fluid. In separate experiments, BRP-39 KO and BALB/c WT mice were room air (white bars) or smoke (black bars) exposed for 2 weeks and concurrently exposed to nebulized OVA. Upon rechallenge following a month of smoke and OVA exposure cessation, cellular inflammation was assessed. (B) Data show total cell numbers (TCN), mononuclear cells (MNC), neutrophils (NEU), and eosinophils (EOS) in the BAL fluid. (C) Lung digests were also generated and analyzed by flow cytometry for the presence of Th2 cells (T1ST2+ IL-5+) and activated dendritic cells (CD86+). n = 5, data in B and C are representative of 2 separate experiments, * indicate P < 0.05.

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Respiratory Research

ISSN: 1465-993X

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