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Table 1 Baseline characteristics of 126 subjects with AATD-associated emphysema

From: Matrix metalloproteinase-9 predicts pulmonary status declines in α1-antitrypsin deficiency

 

Mean ± SD or N (%)

Age, years

53.8 ± 8.5

Female

34 (27%)

Caucasian race

126 (100%)

Tobacco Status

 

   Never Smoker

14 (11%)

   Former Smoker*

112 (89%)

Pack-Years (among former smokers)

19.0 ± 12.4

Body-Mass Index

25.2 ± 4.3

FEV1,% predicted

46.5% ± 16.8%

FEV1/FVC

0.38 ± 0.11

Total Lung Capacity, % predicted

149% ± 45%

GOLD Stage

 

   1

21 (17%)

   2

56 (44%)

   3

47 (37%)

   4

2 (2%)

Transfer Factor (TLco), mmol/min/kpa

4.9 ± 1.6

Transfer Factor, % predicted

48% ± 15%

CT Densitometry

 

   Adjusted Lung Density†

-956.2 ± 16.0

Resting Oxygen Saturation (room air)

93.5% ± 2.8%

Incremental Shuttle Walk Test

 

   Distance Walked, meters

406 ± 203

MMP-9 level (ng mL-1)

 

   Median (25th to 75th Interquartile Range)

28.3 (17.8 - 55.4)

  1. *5 subjects (4%) had quit smoking 6-12 months prior to baseline. The remainder of former smokers had quit smoking >12 months prior to baseline. There were no current smokers by study exclusion criteria.
  2. †Measured in Hounsfield Units at the 15th percentile.
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Respiratory Research

ISSN: 1465-993X

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