Figure 6
Contribution of Cx 37, 40 and 43 in the contractile response to Phe. Concentration-response curves to Phe were performed in the absence (control, squares) or in the presence of connexin-mimetic peptides targeted against Cx 37 and 43 (37-43Gap27, circles) and 40 (40Gap27, triangles). Each set of experiments was performed on intrapulmonary arteries from normoxic (normoxia, panel A, black symbols, n = 11 - 21), chronic hypoxic (chronic hypoxia, panel B, white symbols, n = 14 - 23) and monocrotaline-injected rats (monocrotaline, panel D, grey symbols, n = 7 - 13). Panels C and E summarize the effects of the Gap27 on the contractile changes to Phe from N to CH or from normoxic to MCT rat models respectively. Data are means ± SEM and are expressed as a percentage of the high potassium solution (80 mM)-induced response. * means a significant difference for P < 0.05.