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Figure 4 | Respiratory Research

Figure 4

From: Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension

Figure 4

Contribution of Cx 37, 40 and 43 in the contractile response to 5-HT. Concentration-response curves to 5-HT were performed in the absence (control, squares) or in the presence of connexin-mimetic peptides targeted against Cx 37 and 43 (37-43Gap27, circles) and 40 (40Gap27, triangles). Each set of experiments was performed on intrapulmonary arteries from normoxic (normoxia, panel A, black symbols, n = 12 - 24), chronic hypoxic (chronic hypoxia, panel B, white symbols, n = 8 - 19) and monocrotaline-injected rats (monocrotaline, panel C, grey symbols, n = 9 - 20). Data are means ± SEM and are expressed as a percentage of the high potassium solution (80 mM)-induced response. * means a significant difference for P < 0.05.

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