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Table 4 Effect of anti-co-receptors antibodies on Treg cells, IL-10 and IFN-γ production

From: Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4

 

R (n = 12)

AR (n = 10)

A (n = 11)

 

Derp1

Derp1+ anti-ICOS

Derp1+ anti-CTLA4

Derp1+ anti-CD28

Derp1

Derp1+ anti-ICOS

Derp1+ anti-CTLA4

Derp1+ anti-CD28

Derp1

Derp1+ anti-ICOS

Derp1+ anti-CTLA4

Derp1+ anti-CD28

CD3+IL-10+(%)

3.82 ± 0.49

3.79 ± 0.30

4.66 ± 1.05

3.31 ± 0.32

3.80 ± 0.41

3.54 ± 0.46

3.96 ± 0.50

3.60 ± 0.52

5.03 ± 0.68

4.42 ± 0.56

4.42 ± 0.64

4.37 ± 0.64

CD4+CD25Hi+ Foxp3+ (%)

4.25 ± 0.45

4.49 ± 0.65

4.24 ± 0.57

3.57 ± 0.65

3.61 ± 0.70

4.21 ± 1.13

3.87 ± 0.83

2.78 ± 0.83

2.65 ± 0.47

2.47 ± 0.38

2.55 ± 0.40

1.75 ± 0.29

CD3+IFN-γ+ (%)

7.48 ± 1.15

6.13 ± 0.75

7.24 ± 1.11

7.63 ± 0.98

12.26 ± 1.35

11.86 ± 1.01

13.99 ± 1.84

13.64 ± 1.36

11.90 ± 1.89

10.43 ± 1.78

12.35 ± 1.74

12.32 ± 1.98

CD3+IL-4+ (%)

4.22 ± 0.55

2.01 ± 0.26*

3.67 ± 0.94

2.33 ± 0.40*

3.29 ± 0.49

2.21 ± 0.15***

2.85 ± 0.34

2.41 ± 0.22**

3.53 ± 0.50

2.56 ± 0.54

2.92 ± 0.51

3.11 ± 0.95

  1. PBMC from allergic non asthmatics (R, n = 12), allergic asthmatics (AR, n = 10) and non allergic asthmatics (A, n = 11), were stimulated with Derp 1 and cultured in the presence or absence of anti-ICOS, anti-CTLA4 or anti-CD28 antibodies. Treg cells, IL-10 and IFN-γ production by T-cells were assessed by flow cytometry. Results are expressed as mean of total T-cells ± SE and compared versus absence of anti-co-receptors antibodies conditions. R = allergic rhinitis; A R = allergic asthma and rhinitis. * = p < 0.05, ** = p < 0,01, *** = p < 0,001.
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Respiratory Research

ISSN: 1465-993X

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