Skip to main content
Figure 5 | Respiratory Research

Figure 5

From: Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6

Figure 5

Inhibition of acute but not sustained HPV by the diacylglycerol kinase inhibitor R59949. The effect of the diacylglycerol kinase inhibitor R59949 as well as its solvent on normoxic vascular tone and sustained HPV was investigated for a period of 120 min. (A) Increase in normoxic pulmonary arterial pressure (ΔPAP) referenced to the value directly before R59949 application. For comparison changes in PAP are given for normoxic lungs in the absence of R59949. (B) Strength of sustained HPV in the presence and the absence of R59949. Data are derived from n = 8 isolated lung preparations each. * Significant differences compared to experiments in the absence of R59949 (p < 0.05).

Back to article page