Skip to main content
Figure 5 | Respiratory Research

Figure 5

From: Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma

Figure 5

Functional effects of CAP+O 3 exposure on airways responsiveness to methacholine and attenuation by arginase inhibition. Dose-response relationships for the increase in total lung resistance (R) to methacholine in OVA/PBS (A) and OVA/OVA (B) mice from the sub-acute model exposed to FA or CAP+O3. Effects of treatment with arginase inhibitor (BEC) vs. vehicle control (PBS) on maximum total lung resistance (RMax) in OVA/PBS (â–¡) and OVA/OVA (â– ) mice following CAP+O3 exposures in the sub-acute (C) and chronic (D) models (*P < 0.05, ** P < 0.01, *** P < 0.001; n = 9-12/group).

Back to article page