Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis

Table 4 Responder rates* for TDI^† and ΔSGRQ^† by average ΔFEV₁ category

Average ΔFEV₁ (ml)	Category midpoint value of ΔFEV₁ (ml)	TDI at 12 weeks % responders (n = 2781)	TDI at 24/26 weeks % responders (n = 2208)	TDI at 52 weeks % responders (n = 1099)	ΔSGRQ at 12 weeks % responders (n = 3141)	ΔSGRQ at 24/26 weeks % responders (n = 2215)	ΔSGRQ at 52 weeks % responders (n = 1115)
-500, -50	-275	50	51	45	42	49	41
-50, 50	0	48	49	53	46	45	45
50, 150	100	54	57	50	48	48	49
150, 250	200	59	60	58	53	59	54
250, 500	375	66	69	69	56	57	65

*Responders were patients who achieved at least the minimal clinically important difference (MCID; one and four units for TDI and ΔSGRQ, respectively); TDI, Transition Dyspnoea Index; ΔSGRQ, change from baseline in St George's Respiratory Questionnaire; ΔFEV₁, change from baseline in trough forced expiratory volume in 1 second.
^†For the outcomes, each row contains approximately 20% of the column's indicated n, as in the left half of Table 2

ISSN: 1465-993X