Figure 6

Effects of 17β-estradiol on the Mts1/RAGE pathway in hPASMCs. A: 17β-estradiol (0.3-10 nM) induces an increase in Mts1 protein in hPASMCs. Quantification of data from multiple experiments (n = 4) is shown as mean ± SEM and analysed by one-way ANOVA followed by Dunnetts post-test. *P < 0.05, **P < 0.01 vs control. B: 17β-estradiol (1 nM) induced proliferation of hPASMCs is inhibited in the presence of sRAGE (2.5 μg/ml). Data are shown as mean ± SEM (n = 4) and analysed by one-way ANOVA followed by Dunnetts post-test. **P < 0.01 vs 2.5% serum, ††P < 0.01 vs 1 nM 17β-estradiol.