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Table 1 Characteristics of studies included in the meta-analysis.

From: Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis

Study and reference Ethnicity/Country Age COPD definition Smoking history Methodology of genotyping
Bergen cohort from Pillai et al [26] NR/Norway NR post-bronchodilator FEV1<80% predicted and FEV1/FVC<0.7 a minimum smoking history of 2.5 pack-years Illumina's HumanHap550 BeadChip
Copenhagen City Heart Study from Kaur-Knudsen et al [25] NR/Denmark NR ICD-8 491-492 ICD-10 J41-J44 NR TaqMan method
COPDGene study from Kim et al [24] non-Hispanic white subjects/America 45-80 post-bronchodilator FEV1<80% predicted and FEV1/FVC<0.7 a minimum smoking history of 10 pack-years TaqMan method
COPACETIC cohort from Lambrechts et al [23] NR/the Netherlands 50-75 pre-bronchodilator FEV1/FVC<0.7 a minimum smoking history of 20 pack-years Illumina's HumanHap610-Quad BeadChip
LEUVEN cohort from Lambrechts et al [25] NR/Belgium >50 post-bronchodilator FEV1/FVC<0.7 a minimum smoking history of 15 pack-years iPLEX™ genotyping assay
NETT/NAS cohorts from Pillai et al [26] non-Hispanic white subjects/America NR FEV1 ≤45% predicted and bilateral emphysema on chest CT cases: former smokers
controls: a minimum smoking history of 10 pack-years
Sequenom iPLEX or TaqMan method
New Zealand study from Young et al [27] Caucasian/New Zealand Case: >40; Controls:45-80 post-bronchodilator FEV1<80% predicted and FEV1/FVC<0.7 a minimum smoking history of 15 pack-years iPLEX™ genotyping assay
  1. Abbreviations: NR, not reported; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity