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Figure 6 | Respiratory Research

Figure 6

From: Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

Figure 6

Effects of curcumin and a cathepsin inhibitor on the expression of apoptosis markers in bleomycin stimulated HFL-1 cells. Quantitative analysis of Tunel-positive staining in lungs of curcumin treated bleomycin-induced lung injury (A). Representative immunoblot images and their quantitative analysis (B and C) show that curcumin increases caspase-3, Bax/Bcl-2 expression in a dose-dependent manner. LHVS, a pan-cathepsin inhibitor is able to reverse the proapoptotic effect of curcumin as seen by the reduction of caspase-3 expression and the Bax/Bcl-2 ratio in HFL-1 cells (D). All data represent means of three independent experiments ± SD. (* p < 0.05, all compared to bleomycin treated group only).

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