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Figure 3 | Respiratory Research

Figure 3

From: Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

Figure 3

Effects of curcumin on collagen deposition in fibrotic lungs of mice (bleomycin-induced) and HFL-1 cell proliferation and migration. Representative images of Masson trichrome staining (A) and quantitative image analysis (B) of collagen content in the lungs of 9-10 mice/group display a reduction of collagen by curcumin. MTT assay (C) shows curcumin dose-dependent decrease of proliferation of HFL-1 cells in the presence of bleomycin (0.1 mU/ml) at 24, 48 and 72 h. Cell migration rates (D) of HFL-1 cells were also decreased by curcumin. All the cell-related data represent means of three independent experiments ± SD. The Masson trichrome staining evaluation is based on the image analysis of two tissue section per mouse and data represent means ± SE (* p < 0.05, all compared to bleomycin treated group only).

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Respiratory Research

ISSN: 1465-993X

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