Figure 3

Time course of rectal body temperature during infection. Body temperature of all mice showed a strong decrease, which peaked between 6 and 10 hours post inoculation. Temperature declined in C57Bl/6J mouse strains to a minimum of approximately 25°C (A), in FABP mice the minimal temperature was always higher than 30°C (B). Exceptions were the young Cftr^KO mice with a minimal temperature of 28.5°C at 8 h p.i. In old B6 and Cftr^MHH mice (A, right panel) temperature remained longer at lower values (until 12 h p.i.), although the recovery to physiological level took the same period of time as in the groups of young Cftr^MHH and B6 mice (A, left panel. In summary, the C57BL/6J mouse strains showed a stronger depression of body temperature upon airway exposure with P. aeruginosa than FABP mice.