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Table 2 Baseline values for biomarkers with a significant difference between COPD subjects and either smoking or non-smoking controls.

From: COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

  COPD Subjects Smoker Controls   Non-smoker Controls  
Biomarker N Median (IQR) N Median (IQR) COPD Subjects vs Smoker Controls N Median (IQR) COPD Subjects vs Non-smoker Controls
Adiponectin (ng/mL)* 198 15614.5 (10340.0) 37 10856.0 (6145.0) < 0.001 36 16124.5 (6428.5) 0.270
β-Defensin-2 (pg/mL)* 199 1222.3 (1794.8) 37 771.6 (784.2) 0.003 37 648.2 (964.1) 0.042
CCL2 (pg/mL) 201 615.0 (395.0) 37 530.0 (365.0) 0.065 37 460.0 (445.0) 0.017
CCL18 (pg/mL) 193 96000.0 (93000.0) 37 67000.0 (40000.0) 0.018 35 68000.0 (34000.0) 0.041
C-reactive protein (μg/mL) 200 5.38 (10.62) 37 3.13 (5.27) 0.036 35 2.17 (3.96) 0.002
CXCL10 (pg/mL) 198 79.7 (38.0) 37 67.8 (26.6) 0.085 35 65.8 (30.4) 0.017
Fibrinogen (mg/dL) 200 466.0 (117.5) 37 425.0 (100.0) 0.002 37 387.0 (83.0) < 0.001
Hepatocyte growth factor (pg/mL) 199 589.2 (492.7) 37 475.3 (303.6) 0.324 37 421.7 (217.7) 0.012
Interleukin-6 (pg/mL) 194 0.2 (2.8) 37 0.2 (0.0) 0.004 37 0.2 (0.4) 0.072
Interleukin-8 (pg/mL) 190 8.8 (5.2) 36 7.7 (4.8) 0.051 34 6.7 (3.0) 0.009
Interleukin-12 p40 (pg/mL) 177 1.6 (2.8) 32 2.3 (3.5) 0.343 32 0.6 (2.3) 0.017
Matrix metalloproteinase-8 (pg/mL)* 198 9005.8 (10853.0) 37 7393.7 (7231.2) 0.003 37 6607.9 (5241.8) < 0.001
Matrix metalloproteinase-9 (pg/mL) 201 238020.0 (202960.0) 37 182700.0 (92460.0) 0.198 37 158180.0 (85815.0) < 0.001
Myeloperoxidase (pg/mL) 198 34680.0 (34305.0) 36 24770.0 (19280.0) 0.195 37 20800.0 (17100.0) 0.043
Prolactin (pg/mL) 196 525.0 (462.5) 37 345.0 (260.0) < 0.001 36 580.0 (325.0) 0.771
  1. Values are expressed as median (IQR), p values are based on log transformed results adjusted for age and sex. Biomarkers marked with * were measured at a single timepoint.