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Table 1 Baseline characteristics of the biomarker cohort.

From: COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

Characteristic COPD Subjects Smoker Controls Non-smoker Controls
Number 201 37 37
Age (yrs) 64.5 (6.0) 60.7 (7.6) 60.0 (8.8)
Male (%) 73% 68% 38%
Smoking, pack-years 45.7 (26.9) 29.3 (16.5) 0.0 (0.2)
FEV1 % predicted 43.8 (17.2) 109.6 (12.3) 115.9 (11.9)
% Low attenuation area on CT (< -950HU) 22.7 (13.7) 4.6 (4.5) 5.3 (5.5)
Radiologist Score < 5% emphysema 20% 95% 97%
  5-25% emphysema 18% 5% 0
  25-50% emphysema 15% 0 3%
  > 50% emphysema 48% 0 0
% reversibility FEV1 9.6 (11.2) 3.7 (5.1) 2.2 (4.9)
BMI 26.9 (5.5) 29.2 (4.9) 27.1 (6.1)
Fat free mass index 17.1 (2.6) 18.2 (2.5) 16.8 (2.6)
Number of exacerbations in year prior to enrollment in ECLIPSE 0 46% 100% 97%
  1 26% 0 3%
  2 18% 0 0
  3 or more 10% 0 0
6 min walk (m) 384 (124)   
BODE Index 3.4 (2.2)   
mMRC score 1.9 (1.1) 0.2 (0.5) 0.1 (0.4)
CES-D score 11.5 (9.0) 7.1 (8.8) 5.3 (5.1)
FACIT score 34.8 (10.6) 44.4 (8.4) 47.4 (4.3)
SGRQ-C Total score 52.9 (18.9) 8.4 (11.9) 2.5 (2.3)
  1. BMI = Body Mass Index; BODE = BMI (B), airflow obstruction (O) as measured by the post-bronchodilator FEV1 (percentage of predicted value), dyspnoea (D) assessed by the modified Medical Research Council (mMRC) score, and exercise tolerance (E) measured by 6-minute walking distance; FEV1 = Forced Expiratory Volume in 1 second; SGRQ-C = St. Georges respiratory questionnaire for COPD patients. Values expressed as mean (standard deviation) or as percentage.