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Table 1 AR deficiency decreases cytokines and chemokines levels in the lungs of RWE-challenged mice.

From: Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Cytokine and chemokines

WT Control

AR -/- Control

WT-RWE

AR -/- -RWE

1. IL-1a

1.1 ± 0.5

1.6 ± 1.0

35.2 ± 1.9***

22.0 ± 3.3#

2. IL-2

11.0 ± 0.8

12.4 ± 0.7

19.7 ± 3.1*

12.3 ± 2.0#

3. IL-4

ND¶

ND¶

8.9 ± 0.8*

1.5 ± 0.7#

4. IL-5

1.6 ± 1.6

6.5 ± 1.5

108.5 ± 18.7**

53.0 ± 4.0#

5. IL-6

2.4 ± 1.3

3.2 ± 0.4

67.5 ± 12.1**

27.4 ± 2.4#

6. IL-7

2.4 ± 1.4

2.4 ± 1.3

10.1 ± 0.7**

5.3 ± 0.2#

7. IL-10

2.1 ± 1.8

1.6 ± 1.6

24.0 ± 3.6**

9.7 ± 4.2#

8. IL-13

2.4 ± 1.3

3.2 ± 0.5

76.6 ± 6.5*

15.5 ± 2.3#

9. G-CSF

9.2 ± 1.8

9.5 ± 3.9

842.8 ± 115.4**

239.4 ± 56.0##

10. IP-10

4.0 ± 1.4

4.8 ± 2.1

79.9 ± 14.8**

24.3 ± 3.9#

11. MIP-1

ND¶

0.05 ±0.03

46.3 ± 2.7***

24.5 ± 0.5##

12. KC

2.7 ± 1.7

2.8 ± 1.6

33.1 ± 1.8**

15.6 ± 1.65 ##

13. RANTES

0.9 ± 0.1

1.1 ± 0.7

4.4 ± 1.1*

1.9 ± 0.4#

  1. The levels of cytokines and chemokines in the BAL fluids were measured using the magnetic beads-based multiplex cytokine assay system. Data (pico-gm/mL) are presented as means ± SD (n = 4).
  2. *p < 0.02 vs. WT control mice; **p < 0.008 vs. WT control mice; ***p<0.0002 vs. unchallenged WT control mice; #p<0.03 vs. WT-RWE-challenged mice, ##p<0.005 vs. WT-RWE-challenged mice. ¶ND, non-detectable