Figure 4

AR deficiency blocks inflammatory cells infiltration in RWE-challenged mice lung. Lungs of RWE-sensitized and challenged mice were lavaged and fixed. The fixed lungs were sectioned and stained with H&E. Arrowheads indicate sites of inflammatory cells infiltration induced by RWE-challenge (n = 4-6). RWE, ragweed pollen extract; WT, wild-type; AR^-/-, aldose reductase null mice.