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Figure 1 | Respiratory Research

Figure 1

From: Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Figure 1

AR deficiency prevents methacholine-induced airway hyper-responsiveness in RWE-challenged mice. The changes in PENH were measured by whole-body plethysmography. Mice were placed in a barometric plethysmographic chamber and PENH, an index of airway obstruction, was determined and plotted against the increasing concentration of methacholine. Each data point represents mean±SD of 4 mice for each group. *p < 0.01 vs. WT-RWE. RWE, ragweed pollen extract; WT, wild-type; BL, base line; PENH, enhanced pause.

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