Table 1 The PAH Phenotype in MCT-Injected Rats: Near-Full Prevention by Early Treatment with VIP *
Measurements | Control, untreated | MCT + | P value (post hoc) | |||
|---|---|---|---|---|---|---|
|  |  | 0 | VIP | †| ** | ††|
RV systolic pressure (mm Hg) | 24.3 ± 2.4 | 61.4 ± 4.8 | 29.9 ± 1.8 | < 0.05 | < 0.05 | NS |
Arteriolar medial/luminal area | 0.76 ± 0.07 | 3.9 ± 0.51 | 1.5 ± 0.2 | < 0.05 | < 0.05 | NS |
RV/(LV+septum) weight ratio | 0.26 ± 0.01 | 0.56 ± 0.03 | 0.35 ± 0.01 | < 0.05 | < 0.05 | NS |
Lung inflammation (0-4) | 0.20 ± 0.17 | 3.0 ± 0.26 | 0.3 ± 0.21 | < 0.05 | < 0.05 | NS |