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Figure 1 | Respiratory Research

Figure 1

From: VIP and endothelin receptor antagonist: An effective combination against experimental pulmonary arterial hypertension

Figure 1

Rat lung sections (H&E) showing MCT-induced vascular thickening and its attenuation by VIP, bosentan, or their combination. Small pulmonary arteries from MCT-treated rats had thickened media and narrowed lumen compared to arteries of similar diameter (70-80 μm) from control, untreated rats (A, B, P< 0.001). Treatment with either VIP or bosentan (C, D) resulted in significant attenuation of these changes: the ratio of medial area to luminal area in VIP-treated rats was significantly reduced (P< 0.05). In rats receiving a combination of VIP and bosentan (E), the medial area/luminal area ratio was almost the same as in control untreated rats (magnification: X20).

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Respiratory Research

ISSN: 1465-993X

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