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Figure 3 | Respiratory Research

Figure 3

From: Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression

Figure 3

Effects of Nogo-B knock-down on proliferation, migration and contraction of HBSMCs. A, Untransfected cells or HBSMCs transfected with NEGi or NOGOi-2 for 48 h were starved overnight to achieve growth arrestment and treated with PDGF-BB (20 ng/ml). Cell numbers were counted by proliferation assay. *P < 0.05 compared with untreated control. B, Untransfected cells or HBSMCs transfected with NEGi or NOGOi-2 for 48 hours were starved overnight a treated with PDGF-BB (20 ng/ml) in SmGM to induce migration. C-F, representative pictures of contraction of untreated HBSMCs (C) or PDGF-treated untransfected control (D), NEGi transfected (E), and NOGOi-2 transfected (F) HBSMCs. G, Statistic analysis of the effects of Nogo-B inhibition on the contraction of HBSMsC. All data are mean ± SD, n = 3 for triplicate experiments, *P < 0.05, **P < 0.01 as indicated.

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Respiratory Research

ISSN: 1465-993X

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