Skip to main content

Table 1 Production of cytokines and chemokines by eosinophils stimulated with CXCR3 ligands.

From: IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2integrin and CXCR3

Cytokine

Control (pg/ml)

IP-10 (pg/ml)

Mig (pg/ml)

I-TAC (pg/ml)

IL-1ra

1.8 ± 0.7

25.0 ± 2.1*

3.8 ± 1.3

3.9 ± 0.9

IL-1β

0.3 ± 0.1

6.5 ± 2.5*

2.6 ± 1.0

1.8 ± 0.9

IL-2

0.0 ± 0.0

2.0 ± 0.1*

0.1 ± 0.1

0.1 ± 0.0

IL-4

0.1 ± 0.0

1.1 ± 0.1*

0.1 ± 0.0

0.1 ± 0.0

IL-5

0.0 ± 0.0

0.3 ± 0.1*

0.0 ± 0.0

0.0 ± 0.0

IL-6

9.2 ± 4.9

80.5 ± 27.4*

40.5 ± 17.4

29.5 ± 14.8

IL-7

0.1 ± 0.0

0.9 ± 0.1*

0.2 ± 0.1

0.2 ± 0.0

IL-8

186.8 ± 89.8

404.7 ± 73.3*

315.3 ± 79.7

251.7 ± 76.5

IL-9

1.1 ± 0.2

4.4 ± 0.4*

1.8 ± 0.3

2.2 ± 0.3*

IL-10

0.7 ± 0.2

2.1 ± 0.4*

1.2 ± 0.4

1.7 ± 0.6

IL-12(p70)

0.3 ± 0.1

0.9 ± 0.1*

0.4 ± 0.1

0.3 ± 0.1

IL-13

1.1 ± 0.3

1.8 ± 0.2*

1.4 ± 0.2

1.4 ± 0.2

IL-15

0.2 ± 0.0

0.5 ± 0.1*

0.3 ± 0.1

0.3 ± 0.1

IL-17

0.8 ± 0.2

2.5 ± 0.7*

0.6 ± 0.2

0.7 ± 0.4

Eotaxin

1.7 ± 0.6

23.2 ± 0.5*

2.4 ± 1.1

2.4 ± 0.9

FGF

1.4 ± 0.5

5.6 ± 1.3*

1.1 ± 0.6

3.1 ± 1.1

G-CSF

0.2 ± 0.1

2.5 ± 0.4*

0.5 ± 0.2

0.3 ± 0.2

GM-CSF

0.8 ± 0.3

9.4 ± 1.0*

1.6 ± 0.4

1.7 ± 0.5

IFN-γ

2.6 ± 0.6

107.0 ± 10.3*

5.4 ± 2.1

5.6 ± 2.0

MCP-1

32.6 ± 14.3

86.5 ± 28.7*

65.5 ± 24.6

53.5 ± 22.1

MIP-1α

6.4 ± 2.8

30.7 ± 10.4*

17.8 ± 8.9

14.5 ± 7.9

MIP-1β

93.7 ± 31.0

183.5 ± 19.1*

160.0 ± 24.5*

135.5 ± 25.7

PDGF

0.6 ± 0.3

2.2 ± 0.5*

0.4 ± 0.1

1.2 ± 0.3

RANTES

6.5 ± 0.9

20.3 ± 1.0*

7.8 ± 1.1

7.9 ± 1.0

TNF-α

4.0 ± 1.9

19.2 ± 4.5*

5.3 ± 3.3

2.7 ± 1.0

VEGF

7.8 ± 2.6

13.3 ± 2.5*

10.5 ± 3.3

10.4 ± 2.8

  1. Eosinophils were incubated with CXCR3 ligands for 24 h, and the concentrations of cytokines and chemokines in cell-free supernatants were measured using Bio-plex assay kits. *P < 0.05 versus without CXCR3 ligands.