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Table 1 Production of cytokines and chemokines by eosinophils stimulated with CXCR3 ligands.

From: IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2integrin and CXCR3

Cytokine Control (pg/ml) IP-10 (pg/ml) Mig (pg/ml) I-TAC (pg/ml)
IL-1ra 1.8 ± 0.7 25.0 ± 2.1* 3.8 ± 1.3 3.9 ± 0.9
IL-1β 0.3 ± 0.1 6.5 ± 2.5* 2.6 ± 1.0 1.8 ± 0.9
IL-2 0.0 ± 0.0 2.0 ± 0.1* 0.1 ± 0.1 0.1 ± 0.0
IL-4 0.1 ± 0.0 1.1 ± 0.1* 0.1 ± 0.0 0.1 ± 0.0
IL-5 0.0 ± 0.0 0.3 ± 0.1* 0.0 ± 0.0 0.0 ± 0.0
IL-6 9.2 ± 4.9 80.5 ± 27.4* 40.5 ± 17.4 29.5 ± 14.8
IL-7 0.1 ± 0.0 0.9 ± 0.1* 0.2 ± 0.1 0.2 ± 0.0
IL-8 186.8 ± 89.8 404.7 ± 73.3* 315.3 ± 79.7 251.7 ± 76.5
IL-9 1.1 ± 0.2 4.4 ± 0.4* 1.8 ± 0.3 2.2 ± 0.3*
IL-10 0.7 ± 0.2 2.1 ± 0.4* 1.2 ± 0.4 1.7 ± 0.6
IL-12(p70) 0.3 ± 0.1 0.9 ± 0.1* 0.4 ± 0.1 0.3 ± 0.1
IL-13 1.1 ± 0.3 1.8 ± 0.2* 1.4 ± 0.2 1.4 ± 0.2
IL-15 0.2 ± 0.0 0.5 ± 0.1* 0.3 ± 0.1 0.3 ± 0.1
IL-17 0.8 ± 0.2 2.5 ± 0.7* 0.6 ± 0.2 0.7 ± 0.4
Eotaxin 1.7 ± 0.6 23.2 ± 0.5* 2.4 ± 1.1 2.4 ± 0.9
FGF 1.4 ± 0.5 5.6 ± 1.3* 1.1 ± 0.6 3.1 ± 1.1
G-CSF 0.2 ± 0.1 2.5 ± 0.4* 0.5 ± 0.2 0.3 ± 0.2
GM-CSF 0.8 ± 0.3 9.4 ± 1.0* 1.6 ± 0.4 1.7 ± 0.5
IFN-γ 2.6 ± 0.6 107.0 ± 10.3* 5.4 ± 2.1 5.6 ± 2.0
MCP-1 32.6 ± 14.3 86.5 ± 28.7* 65.5 ± 24.6 53.5 ± 22.1
MIP-1α 6.4 ± 2.8 30.7 ± 10.4* 17.8 ± 8.9 14.5 ± 7.9
MIP-1β 93.7 ± 31.0 183.5 ± 19.1* 160.0 ± 24.5* 135.5 ± 25.7
PDGF 0.6 ± 0.3 2.2 ± 0.5* 0.4 ± 0.1 1.2 ± 0.3
RANTES 6.5 ± 0.9 20.3 ± 1.0* 7.8 ± 1.1 7.9 ± 1.0
TNF-α 4.0 ± 1.9 19.2 ± 4.5* 5.3 ± 3.3 2.7 ± 1.0
VEGF 7.8 ± 2.6 13.3 ± 2.5* 10.5 ± 3.3 10.4 ± 2.8
  1. Eosinophils were incubated with CXCR3 ligands for 24 h, and the concentrations of cytokines and chemokines in cell-free supernatants were measured using Bio-plex assay kits. *P < 0.05 versus without CXCR3 ligands.