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Figure 2 | Respiratory Research

Figure 2

From: IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2integrin and CXCR3

Figure 2

Anti-β 2 integrin mAb and anti-CXCR3 mAb suppress eosinophil adhesion enhanced by ICAM-1 and IP-10. (A) IP-10-enhanced eosinophil adhesion to ICAM-1 is inhibited by anti-β2 integrin mAb. Eosinophils were pre-incubated with either anti-integrin mAb (3 μg/ml) or control IgG for 15 min prior to analysis of adhesion in the presence or absence of IP-10. Data are shown as means ± SEM of 6 experiments using cells from different donors. (B) IP-10-enhanced eosinophil adhesion to ICAM-1 is inhibited by anti-CXCR3 mAb. Eosinophils were pre-incubated with either anti-CXCR3 mAb (3 μg/ml) or control IgG for 15 min prior to analysis of adhesion in the presence or absence of IP-10. Data are shown as means ± SEM of six experiments using cells from different donors. Open and filled bars, eosinophil adhesion without and with IP-10, respectively. **P < 0.01 versus without IP-10. ##P < 0.01, ###P < 0.001 versus mouse IgG1.

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