Changes in granuloma size and numbers. Granulomas in Apoe-/- (A), Apoe-/-Ctsk-/- (B) and Apoe-/-Ctsl-/- mice after 16 weeks on HFD (C). (D), size of granulomas was significantly smaller in cathepsin K- and L-deficient mice. (E), number of granulomas in cathepsin L-deficient mice was dramatically decreased. (F), granulomas in Apoe-/- mice after 8 weeks on HFD. (G), Apoe-/- mice treated with cathepsin S inhibitor developed only individual epithelioid cells after 8 weeks on HFD. (A-C, F, G), trichrome stained sections, scale bars 65 μm. * - p < 0.05 when compared to Apoe-/- mice.