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Table 2 Association of concurrent asthma diagnosis and COPD severity outcomes in COPD subjects.

From: The clinical features of the overlap between COPD and asthma

Outcome Additional Covariates β(SE)/OR(CI) p-value
BODE Index age, gender, pack-years and race 0.29 (0.21) 0.17
SGRQ age, gender, pack-years and race 5.2 (2.0) 0.009
6MWT, ft age, gender, pack-years and race 31.6 (40.5) 0.43
Bronchodilator Response age, gender, pack-years, and race 1.40[0.92, 2.13] 0.12
Severe exacerbations age, gender, pack-years and race 1.93 [1.24, 3.02] 0.004
Frequent exacerbations age, gender, pack-years and race 3.55 [2.19, 5.75] < 0.0001
Number of exacerbations age, gender, pack-years and race 0.68 (0.12) < 0.0001
Percent Emphysema, -950HU BMI, age, gender, pack-years, race and CT scanner* -0.45 (1.23) 0.71
Percent gas-trapping, -856HU BMI, age, gender, pack-years, race and CT scanner 4.31 (1.88) 0.02
Airway wall thickness Pi10 BMI, age, gender, pack-years, race and CT scanner 0.016 (0.013) 0.21
  1. Abbreviations and definitions: COPD = chronic obstructive pulmonary disease; BODE index = body mass index, airflow obstruction, dyspnea and exercise capacity index; SGRQ = St George's Respiratory Questionnaire; 6MWT = 6 minute walk test; Severe Exacerbations = presence of COPD exacerbation resulting in presentation to emergency room or hospital admission in year prior to presentation; Frequent exacerbations = two or more COPD exacerbations in the year prior to enrollment; Number of exacerbations = number of COPD exacerbations in the year prior to enrollment; Pi10 = square root wall area of a hypothetical airway of 10 mm internal perimeter. *Siemens 64 Sensation scanners gave aberrant lung density measurements and therefore this scanner type was adjusted as a covariate.