Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment

Respiratory Research

Table 3 The significantly differentially expressed proteins in untreated asthmatics compared to healthy controls

Swiss Prot Acc. No.	Symbol	Entrez Gene Name	Fold Change	Location	Protein Class
P08758	ANXA5	annexin A5	-1.98	Plasma membrane	transfer/carrier protein
Q07507	DPT	dermatopontin	-2.15	Extracellular space	extracellular matrix binding protein
Q96KK5	HIST1H2AH	histone cluster 1, H2ah	-2.85	Nucleus	histone
P02545	LMNA	lamin A/C	-1.85	Nucleus	structural protein
P62937	PPIA	peptidylprolyl isomerase A (cyclophilin A)	-1.64	Cytoplasm	isomerase
P18124	RPL7	ribosomal protein L7	-1.82	Cytoplasm	ribosomal protein
P62917	RPL8	ribosomal protein L8	-1.76	Cytoplasm	ribosomal protein

All listed proteins showed a statistically significant difference (p value < 0.05) between the groups using a Student's t-test. The fold change for each protein is calculated by dividing the average ratio of the untreated asthmatics with the average ratio of the healthy controls. The negative fold change indicates down regulation of protein expression in asthmatic patients. The cell location of the protein is annotated by IPA. The protein class is determined using the PANTHER Classification System.

ISSN: 1465-993X