Figure 4

Network of differentially expressed proteins of post placebo compared to paired pre placebo biopsy. The top network generated by Ingenuity Pathways Analysis from quantified proteins of post placebo asthmatics compared to their pre placebo biopsy. The network contains the functions of hair and skin development and function, organ development, dermatological diseases and conditions. Molecules with bold outline are significantly different between the two groups using a Student's t-test. Lines indicate relationships between molecules. Arrows at the end of these lines indicated the direction of the interaction. Molecules that are up-regulated and down-regulated in the dataset are coloured red and green respectively. Grey molecules do not meet the cut-off threshold. Uncoloured molecules have been added from the IPA KB. Entrez gene names for molecules are: CFL1 = cofilin 1 (non-muscle) DES = desmin, E2F7 = E2F transcription factor 7, HDGF = hepatoma-derived growth factor, HRG = histidine-rich glycoprotein, IGHG3 = immunoglobulin heavy constant gamma 3 (G3 m marker), IGHG4 = immunoglobulin heavy constant gamma 4 (G4 m marker), IGKC = immunoglobulin kappa constant, KRT2 = keratin 2, KRT4 = keratin 4, KRT5 = keratin 5, KRT8 = keratin 8, KRT9 = keratin 9, KRT13 = keratin 13, KRT14 = keratin 14, KRT15 = keratin 15, KRT17 = keratin 17, KRT19 = keratin 19, KRT6A = keratin 6A, PPIF = peptidylprolyl isomerase F, PPL = periplakin, S100P = S100 calcium binding protein P, SERPINA4 = serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4, TACSTD2 = tumor-associated calcium signal transducer 2, TMOD2 = tropomodulin 2 (neuronal), TNFSF13B = tumor necrosis factor (ligand) superfamily, member 13b, TPI1 = triosephosphate isomerase 1, TPM1 = tropomyosin 1 (alpha).