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Figure 6 | Respiratory Research

Figure 6

From: Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

Figure 6

Increased pulmonary inflammation in SPC-sICAM-1 mice after K. pneumoniae infection is due to recruitment of both mononuclear cells and neutrophils. SPC-sICAM-1 mice and wild-type mice were intranasally inoculated with 250 CFU of K. pneumoniae. After 24 hours, the animals were euthanized, and whole lung lavage was performed. Cells were examined by flow cytometry with a gating strategy to identify leukocyte subpopulations as described in materials and methods (a, representative plot, SPC-ICAM-1 at 24 hours). SPC-sICAM-1 had greater accumulation of neutrophils (b), AM (c), and monocytes (d), compared to wild-type at 24 hours, although the differences in AM and monocyte numbers did not reach statistical significance. Data are expressed as mean ± SEM. (n = 6 in all groups; * P < 0.05 compared to wild-type).

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Respiratory Research

ISSN: 1465-993X

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