Year of publication | First Author reference | Study period | Type of study | Focus | Number of patients | Main findings |
---|---|---|---|---|---|---|
2005 | Crothers K [32] | 1999-2000 | Observational study prospective cohort | Respiratory symptoms | 867 | Smoking associated with increase in respiratory symptoms; cough and dyspnea found in 44% of smokers and 25% of non smokers |
2006 | Crothers K [31] | 2001-2002 | Observational study Prospective Case-control Cohort | COPD (self-assessment and coding data) | 1014 (713 controls) | Self-assessment: prevalence of COPD significantly higher in HIV-infected patients (15% vs 12%, p = 0.04); HIV infection = independent risk factor for COPD |
2009 | George MP [33] | 2003-2004 | Observational study Prospective | Respiratory symptoms. airway obstruction | 234 | Prevalence of airway obstruction: 6.8%. Age, pack-years, history of bacterial pneumonia and HAART = independent risk factors for airway obstruction |
2009 | Morris A [43] | NR | Observational study Prospective | Pneumocystis colonization and airway obstruction | 42 | Colonization by Pneumocystis jirovecii (26% of cases) associated with increase in airway obstruction and sputum metalloprotease (MMP 12) levels |
2010 | Drummond MB [36] | 1988-? | Observational study Prospective Cohort Case-control | Respiratory symptoms. Airway obstruction | 288 (686 controls) | Prevalence of airway obstruction: 15.5%. No influence of HIV status |
2010 | Cui Q [35] | NR | Observational study Prospective | Respiratory symptoms. Airway obstruction | 119 | No acceleration of FEV1 decline relative to published data for general population |
2010 | Gingo RM [34] | 2007-2009 | Cross-sectional analysis | Airway obstruction | 167 | 64% of patients had impaired diffusion. 21% of patients had irreversible airway obstruction. Irreversible airway obstruction was independently associated with HAART, pack-years smoked and intravenous drug use. |
2011 | Crothers K [37] | 1999-2007 | Observational study prospective Cohort Case-control | Coding data | 3707 (9980 controls) | HIV-infected patients more likely to have diagnoses of COPD (20.3 per 1000 person-years versus 17.5 per 1000 person-years - p < 0.001). |