Table 1 Main published studies on COPD-HIV interaction in the pre-HAART era
Year of publication | First author Reference | Study period | Type of study | Focus | Number of patients | Main findings |
|---|---|---|---|---|---|---|
1993 | Moscato G [12] | NR | "One day" Case-control | Bronchial hyper-responsiveness | 25 (25 controls) | Prevalence of bronchial hyper-responsiveness identical in the two populations |
1997 | Wallace JM [11] | 1988-1994 | Cohort Case-control | Bronchial hyper-responsiveness | 62 (62 controls) | Prevalence of bronchial hyper-responsiveness identical in the two populations |
2001 | Poirier CD [10] | 1995-1996 | prospective Case-control | Bronchial hyper-responsiveness | 248 (236 controls) | Prevalence of bronchial hyper-responsiveness identical in the two populations Among smokers, bronchial hyper-responsiveness more frequent in HIV-infected men than in controls |
2003 | Diaz PT [13] | 1993-1998 | Cohort Case-control | Chronic bronchitis | 327 (52 controls) | Chronic bronchitis more frequent in HIV-infected patients than in controls (26.9% versus 13.5%, p < 0.05) |
1998 | Shaw RJ [16] | NR | Prospective? descriptive | Airway obstruction | 34 | Lung infections (PCP, bacterial pneumonia) associated with lower FEV1 and peak flow rates |
1988 | O'Donnell CR [14] | 1983-1986 | Retrospective? | Airway obstruction | 99 (AIDS) | Estimated prevalence of lower forced expiratory. flow rates: 33% |
1999 | Gelman M [15] | NR | Prospective Case-control | Air trapping/CT | 48 (11 controls) | Degree of air trapping correlated with duration of HIV infection |
2000 | Hnizdo E [18] | 1995-1996 | Cohort Case-control | Impairment of lung function and tuberculosis | 305 (1038 controls) | Functional respiratory decline due to tuberculosis not aggravated by HIV co infection |
2000 | Morris AM [17] | 1988-1994 | Cohort descriptive | Airway obstruction | 141 | Acceleration of decline in FEV1, FVC and FEV1/FVC, for several months after acute episode |
1989 | Kuhlman JE [21] | NR | Retrospective descriptive | Emphysema CT findings | 55 | CT signs of emphysema, bullous lesions and cysts in 42% of cases |
1996 | Guillemi SA [22] | NR | Prospective descriptive | Emphysema CT findings | 32 | CT signs of emphysema in 31% of cases |
1999 | Diaz PT [20] | NR | Prospective Case-control | Emphysema | 96 (30 controls) | CT signs of emphysema in 50% of cases in patients with reduced DL, CO |
2000 | Diaz PT [23] | 1994-1997 | Prospective Case-control | Emphysema | 114 (44 controls) | Increased incidence of emphysema in the HIV-infected population (15% versus 2% in controls (p = 0.025)). |
1993 | Nieman RB [25] | 1986-1991 | Cohort descriptive | TL, CO | 84 (AIDS) | Decline in TL, CO significantly associated with more rapid progression to AIDS |
1993 | Mitchell DM [27] | NR | Cohort descriptive | DL, CO | 474 | DL, CO decline in case of acute respiratory disease. Decline not specific for PCP diagnosis. |
1995 | Rosen MJ [29] | 1988-1994 | Prospective Case-control | DL, CO | 1127 (167 controls) | CD4 < 200/mm3, ethnic origin, smoking, IV drug use associated with DL, CO decline |