Figure 4From: Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defectTTF-1 expression. Lung tissue immunolabeled with anti-TTF-1 antibody (green) and nuclear labelling (Hoechst 33342, blue), confocal microscopy. a-b: TTF-1 expression in normal lung is confined to nuclear districts. c-d: TTF-1 protein distribution in patient's lung is markedly decreased in alveolar type II cell nuclei (c) and predominantly confined in their cytoplasm. Magnification bar: 20 μm.Back to article page