Table 3 Correlation between AHR to mannitol expressed by the response-dose ratio (RDR) and markers of airway inflammation
From: Airway inflammation and mannitol challenge test in COPD
r | p- value | |
|---|---|---|
FEV1 (% predicted) | -0.09 | 0.67 |
Log FeNO | 0.67 | 0.0002* |
Hypertonic saline-induced sputum | ||
Log (104/g) eosinophils | 0.47 | 0.03* |
Log (104/g) lymphocytes | 0.18 | 0.45 |
Log (104/g) macrophages | 0.27 | 0.24 |
Log (104/g) neutrophils | 0.25 | 0.28 |
Log (104/g) epithelial cells | 0.38 | 0.10 |
Log (ng/ml) ECP | 0.39 | 0.09 |
Log (pg/ml) IL-8 | 0.46 | 0.04* |
Log (ng/ml) MPO | 0.33 | 0.14 |
Mannitol- induced sputum | ||
Log (104/g) eosinophils | 0.71 | 0.001* |
Log (ng/ml) ECP | 0.72 | 0.001* |
Log (pg/ml) IL-8 | 0.57 | 0.015* |
Log (ng/ml) MPO | 0.64 | 0.007* |
Venous blood | ||
Log (%) eosinophils | 0.38 | 0.06 |
Log (%) neutrophils | -0.23 | 0.26 |