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Table 2 Endothelial Cell Biology PCR Array

From: Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells

Biological process description

Gene name

Gene symbol

Public ID

P-value

Endothelial Cell Activation:

Thrombin Activity

Annexin A5

ANXA5

NM_001154

0.023464

Endothelial Cell Injury:

Response to Stress

Anti-Apoptosis

B-cell CLL/lymphoma 2

BCL2

NM_000633

0.000247

Endothelial Cell Activation:

Adhesion Molecules

Cadherin 5, type 2 (vascular endothelium)

CDH5

NM_001795

0.003968

Endothelial Cell Activation:

Adhesion Molecules

Collagen, type XVIII, alpha 1

COL18A1

NM_030582

0.004024

Endothelial Cell Activation:

Adhesion Molecules

Chemokine (C-X3-C motif) ligand 1

CX3CL1

NM_002996

0.000779

Endothelial Cell Activation:

Adhesion Molecules

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

ITGA5

NM_002205

0.000147

Endothelial Cell Activation:

Adhesion Molecules

Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

ITGAV

NM_002210

0.02125

Endothelial Cell Activation:

Adhesion Molecules

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

ITGB1

NM_002211

0.018399

Endothelial Cell Activation:

Extracellular Matrix (ECM) Molecules

Matrix metallopeptidase 1 (interstitial collagenase)

MMP1

NM_002421

0.021783

Permissibility and Vessel Tone:

Regulation of Blood Pressure

Regulation of Vascular Permeability

Angiogenesis:

Negative Regulation of Angiogenesis

Endothelial Cell Activation:

Extracellular Matrix (ECM) Molecules

Natriuretic peptide precursor B

NPPB

NM_002521

0.041345

Angiogenesis:

Other Genes Involved in Angiogenesis

Placental growth factor

PGF

NM_002632

0.029734

Endothelial Cell Injury:

Response to Stress

Phospholipase A2, group IVC (cytosolic, calcium-independent)

PLA2G4C

NM_003706

0.014626

Endothelial Cell Activation:

Extracellular Matrix (ECM) Molecules

Thrombin Activity

Plasminogen activator, urokinase

PLAU

NM_002658

0.039877

Endothelial Cell Activation

Adhesion Molecules

Angiogenesis:

Positive Regulation of Angiogenesis

Endothelial Cell Activation:

Adhesion Molecules

Endothelial Cell Injury:

Other Genes Related to Apoptosis

Ras homolog gene family, member B

RHOB

NM_004040

0.035874

Endothelial Cell Injury:

Response to Stress

Superoxide dismutase 1, soluble

SOD1

NM_000454

0.001855

  1. Functional classification of low expressed genes in co-cultured HPMVECs with MFLCs in comparison to PAFLCs