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Figure 8 | Respiratory Research

Figure 8

From: Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis

Figure 8

Effects of mice treatment with the PAF antagonist WEB 2086. Mice treatment with a PAF antagonist reduced significantly the concentrations of PAI-1 (A) and of inflammatory cells (B), as well as the procoagulant activity (C) detected in BALF from mice infected with the ExoU-producing PA103 bacteria. * p < 0,05, **, p < 0.01 and *** p < 0,001 when the results from PA103-infected mice pretreated with WEB (WEB +) were compared with those from untreated mice (WEB -), or when data obtained from PA103-infected mice were compared with those from controls or from PA103ΔexoU-infected animals. Each group contained at least 11 animals. Data represent mean values ± SE of the results obtained in three different assays.

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Respiratory Research

ISSN: 1465-993X

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