ExoU-induced antifibrinolytic activity in mice airways. In (A) it is shown that TFPI concentrations in BALF from mice infected with PA103 (n = 12) and PA103ΔexoU (n = 12) were significantly higher than concentrations in BALF from control mice (n = 13), but did not differ from each other. * p < 0.05 and ** p < 0.01 when infected mice were compared with control mice. In contrast, in (B) it is shown that PAI-1 concentration in BALF from mice infected with the ExoU-producing PA103 was significantly increased. ** p < 0.01 and *** p < 0,001 when mice infected with PA103 were compared with those infected with the bacterial mutant or with control mice. Data represent mean values ± SE of the results obtained in three different assays.