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Figure 4 | Respiratory Research

Figure 4

From: Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis

Figure 4

ExoU-induced antifibrinolytic activity in mice airways. In (A) it is shown that TFPI concentrations in BALF from mice infected with PA103 (n = 12) and PA103ΔexoU (n = 12) were significantly higher than concentrations in BALF from control mice (n = 13), but did not differ from each other. * p < 0.05 and ** p < 0.01 when infected mice were compared with control mice. In contrast, in (B) it is shown that PAI-1 concentration in BALF from mice infected with the ExoU-producing PA103 was significantly increased. ** p < 0.01 and *** p < 0,001 when mice infected with PA103 were compared with those infected with the bacterial mutant or with control mice. Data represent mean values ± SE of the results obtained in three different assays.

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Respiratory Research

ISSN: 1465-993X

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