Table 3 Polymorphisms associated with the RNASE3 gene

rs2284954

A/G

-550A > G

promoter

rs11575981

C/T

-393T > C

promoter, disrupt C/EBP binding site, correlate with s-ECP [142]

rs2233858

C/T

intron

rs2233859/rs17792481

A/C

-38C > A

intron (in a GATA-1 site) ^a

rs2073342

C/G

371G > C, 434G > C

protein coding, Y > G is associated with allergic asthma [40]^a, poor outcome in oral squamous cell carcinoma tumours [146], C over represented in helminth infected Ugandans [148]

rs12147890

A/G

protein coding

rs2233860

G/C

3' UTR,G is correlated to higher intracellular ECP [143], G is associated with allergic rhinitis [145], ^a

rs8019343

A/T

499G > C, 562G > C

3' UTR T is only present in one patient with helminth infection [147]