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Table 1 ECP level in biological fluids and tissues

From: Analysing the eosinophil cationic protein - a clue to the function of the eosinophil granulocyte

Biological Fluid

ECP concentration (ng/mL)

Eosinophils (×10 6)/mL

Plasma

   Normal value

3.5

0.104 (±0.033) [112]

   Ongoing asthma/allergy

3.5

N/A [43]

   S. mansoni infection

27

0.4 (0.2-0.8) [156]

   Reactive eosinophilia with a inflammation

75

1.9 (±3.2) [112]

   HES

243

19.9 (±10.9) [112]

Serum

   Normal value

7

N/A

   Ongoing allergy/asthma

15

N/A [43]

   S. mansoni infection

~62

0.163

   Atopic Dermatitis inflammation

~50

0.315

   Bacterial infection

~19

N/A [72]

   HES

45- 198

22-58 percent of total cells [111]

   Renal tumour

~30

N/A [123]

BALF

   Normal value

~4

0.2 (±0.1)

   Atopic asthma (challenged)

~40

55.0 (±34.3) [97]

   Drug-induced ARDS

13.8

4 percent of total cells [78]

Sputum

   Normal value

95

0.2 percent of total cells

   Asthma

735

13.4 percent of total cells

   Eosinophil bronchitis

604

12.4 percent of total cells [157]

   Experimental Viral Day -5

119.1 (8.9-1,146)

9.3 (0-30.3) percent of total cells

   Rhinovirus infection Day 2

190.6 (17.2-800) b)

7.5 (0.1-34.4) percent of total cells

   Day 9

157.9(27.8-800)

5.5 (0.4-23.3) percent of total cells [136]

Nasal lavage

   Normal value

3-31

N/A [158]

   Allergic rhinitis

9 ± 2.4

19 (±2.1) percent of total cells

   Allergic rhinitis 6 hr after allergen challenge

36.6 ± 12

56.7 (±5.8) percent of total cells [159]

Nasal secretions

   Normal value

56.2 (33.5-94.2)

 

   RSV infection

379 (269-532) [75]

 

   Natural cold

13038

 

   Severe community acquired bacterial sinusitis

117 704 [77]

 

Tears

   Normal value

<20

1 (±0.2) cells/mm2 in subepithelium [160]

   Atopic keratoconjunctivitis

215 (36-1900) [161]

N/A

   Vernal keratoconjunctivitis

470 (19-6000) [161]

112 (±37) cells/mm2 in subepithelium [160]

Skin, cutaneous

   Normal

N/A

 

   Atopic dermatitis

>16 000 [64]

 
  1. ECP measurements in various biological fluids. Type of fluid, concentration of ECP measured and number of eosinophils are presented.
  2. a) Patients with asthma, atopic dermatitis, lung disease, GI diseases, idiopathic/autoimmune inflammatory conditions
  3. b) Statistically significant increase