Figure 5From: Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomographyAirway narrowing measured in the most distal and proximal airways within the bronchial airway preparation. Airway narrowing was induced by carbachol administered to either (A) adventitial (N = 4) or (B) luminal (N = 4) airway surface. Airway narrowing was quantified from the percentage decrease in luminal cross sectional area (% CSA). Airway narrowing recordings were somewhat later in the proximal airway since aOCT scans were initiated from the distal airway (i.e., proximal recordings occurred ~1 min and 3 min later for luminal and adventitial protocols, respectively). Airway narrowing was greater in distal airways irrespective of whether the drug was applied to the adventitial (P < 0.05) or luminal (P < 0.001) surface. (Two-way ANOVA).Back to article page