Figure 1
An H 4 R antagonist therapeutically decreases Th2 associated cytokines from BAL fluid and lung tissue. An H4R antagonist therapeutically decreases Th2 associated cytokines from BAL fluid and lung tissue in a sub-chronic model of allergic airway inflammation. (A) Model schematic (B) Cell free BAL fluid from vehicle, anti-IL-13 and JNJ 7777120 treated mice (5, 20 and 50 mg/kg) was assayed for the indicated cytokines by using ELISA. (C) Lung homogenates from the same animals were assayed for cytokine content and corrected for total protein. n = 8-10. Significance of each treatment group compared to control vehicle-treated animals is as follows: * P < 0.05; ** P < 0.01; ND = Not determined.