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Table 1 Characteristics of subjects

From: Corticosteroid suppression of lipoxin A4 and leukotriene B4from alveolar macrophages in severe asthma

  Normal Non-Severe asthma Severe asthma
n 14 12 11
Age (yr) 21 ± 0.4 43 ± 3 47 ± 3
Atopy 0/14 11/12 9/11
M/F 12/2 7/5 4/7
FEV 1 (% Predicted) 98 ± 3 85 ± 3 58 ± 6*
PC 20 (mg/ml) >16 5.73 ± 2.7 0.64 ± 0.14*
Inhaled corticosteroid
BDP equivalent (μg/day)
0 527 ± 239
(n = 6)
2400 ± 414*
(n = 11)
Oral prednisolone (mg/day) 0 0 19.1 ± 3.2
(n = 6)
Total BAL Cells
(× 106)
9.19 ± 1.4 8.36 ± 0.8 6.1 ± 0.99
BAL-Macs (×106) 9.02 ± 1.32 8.17 ± 0.76 5.81 ± 1.00
BAL-Neu (×106) 0.1 ± 0.03 0.063 ± 0.016 0.15 ± 0.03
BAL-Eos (×106) 0.018 ± 0.012 0.026 ± 0.012 0.07 ± 0.03
BAL-Mac (%) 97.9 ± 0.5 97.8 ± 0.4 92.9 ± 1.5**
BAL-Neu (%) 1.03 ± 0.3 0.8 ± 0.2 3 ± 0.7*
BAL-Eos (%) 0.21 ± 0.09 0.29 ± 0.14 1.4 ± 0.55*
  1. Abbreviations: M = Male; F = Female; BAL = Bronchoalveolar lavage; BDP = Beclomethasone dipropionate; Neu = neutrophils; Eos = eosinophils; Mac = macrophage. Data shown as mean ± SEM. *p < 0.05; **p < 0.01 compared to non-severe asthma.