Figure 4

Individual levels of LTB ₄ measured after LPS in the absence or presence of dexamethasone (10 ^-6 M) from alveolar macrophages stimulated by LPS in normal subjects (n = 9), non-severe asthmatics (n = 9) and severe asthmatics (n = 8). In the asthmatic groups, closed symbols indicate those on regular treatment with inhaled and/or oral corticosteroids. Data shown as mean ± SEM. Panel C. Mean degree of suppressibility of LXA₄ and LTB₄ release by dexamethasone. Data is expressed as % of LXA₄ or LTB₄ release after exposure to LPS (level after LPS minus basal level) and shown as mean ± SEM.